S2 – Intrinsically disordered proteins: advances and state-of-the-art of the field
Date: Saturday September 8, 2018
Time: 9:00 – 17:00
Intrinsically disordered proteins and protein regions (IDPs/IDRs), characterized by their lack of stability of secondary and tertiary structure in their native unbound state, cover almost a third of the residues in Eukaryotic proteomes. Over the last two decades, IDPs have developed from being bespoke projects of biophysicists interested in protein (non-)folding to being recognized as a major determinant in cellular regulation. As major players in protein homeostasis and cellular signaling, IDPs are involved in numerous diseases.The IDP-SIG is based on previous work from the COST Action NGP-net, a community spanning 30 countries, and also including EMBL Heidelberg and EMBL-EBI. NGP-net maintains databases, develops tools and links community members in the field of IDP research. . Despite significant improvements in our understanding of IDPs in the last 20 years, IDP research is still providing several important research challenges for computational biologists, including classifications, database management, and predicting specific functions of IDPs. The IDP-SIG will assemble members of the IDP community to showcase the current state of the field, stimulate the development of the next generation of prediction methods and drive the the community-driven definition of standards and format for the dissemination of information on IDP experiments.